THE BASIC PRINCIPLES OF NAD+ AND ITS ROLE IN MITOCHONDRIAL FUNCTION

Upcoming, we handled cells with unique concentrations of NAD+. When included for 24 h at 80 µM in HeLa and 400 µM in U2OS cells, NAD+ impaired the incorporation of EdU (Fig. 2a and Extended Facts Fig. 1k,l). In addition, sixteen µM of NAD+ was adequate to lessen fork velocity by ~40% in HeLa cells with out impacting the overall degree of